Self-Emulsifying Drug Delivery Systems (SEDDS) for Oral Delivery of Lipid Based Formulations - A Review
نویسندگان
چکیده
More than 60% of drugs have lipophilic nature and exhibit poor water-solubility. The dissolution is the rate limiting step in their absorption and oral bioavailability. To overcome this problem one approach to enhance dissolution is Self-Dispersing Lipid Formulations (SDLFs). Generally, an emulsified dosage form is rapidly absorbable; therefore, it makes sure that a poorly water-soluble drug is rapidly transported into the circulation. SDLFs consist of a mixture of oil and surfactant, in which active drug moiety is incorporated. They get emulsified under conditions of gentle agitation, similar to those which would be encountered in the gastrointestinal tract on mixing with biological fluids. In this review article introduction, advantages and uses of SDLFs to enhance the dissolution and oral bioavailability are overviewed.
منابع مشابه
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